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Products

Solid-Phase Acylating Agents: Immobilized 1-Hydroxybenzotriazole-6-carboxylic Acid

  

Aurora has developed a line of novel functionalized solid phase acylating reagents. Si-HOBt (Catalog # H 1002, 1-hydroxybenzotriazole-6-carboxamidopropyl silica gel) and Cellulose-HOBt (Catalog # H 1002-DSK-05, 1-hydroxybenzotriazole-6-carboxylate cellulose ester) are utilized for the formation of immobilized activated ester and sulfonate ester reagents for the facile formation of amides and sulfonamides, respectively. The immobilized HOBt is activated utilizing standard coupling chemistry with carboxylic acids (or sulfonyl chlorides) followed by reaction with amines to generate high yields of pure amide and sulfonamide products after filtration. Immobilized HOBt is quite suitable for combinatorial synthesis applications.  Si-HOBt and Cellulose-HOBt offer distinct advantages over polystyrene reagents and other silica gel bound acylating agents. 

  

Why Si-HOBt and Cellulose-HOBt reagents? 


Si-HOBt and Cellulose-HOBt offer distinct advantages over polystyrene reagents and other silica gel bound acylating agents:

1) Recyclable: Used Si-HOBt is readily regenerated for further use. 

2) Solvent Independent: Works with a wide variety of solvents, including aqueous mixtures, without shrinking or swelling. 

3) Ease of Use: Can be used in a flow-through capacity or agitated by shaking. Furthermore, Si-HOBt is also amenable to overhead stirring and even using magnetic stirrers for up to four hours. 

4) Reproducibility and Scalability: Reactions perform the same on small and large-scale applications. What works in the lab will work in production.

5) Green Chemistry: The ability to easily minimize solvent use results in less waste generated. Compatible with “green solvents” such as 2-methyltetrahydrofuran, ethyl acetate and ethanol.


Educational applications may be found here. Immobilized HOBt products can be found in our shop.

Alcohol Diagnostics

Alcohol Diagnostics

Alcohol Diagnostics

G-Mark Product Line – calibration standards and tools for alcohol use detection.

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Phthalate Standards

Alcohol Diagnostics

Alcohol Diagnostics

Phthalates, commonly used as plasticizers, have come under scrutiny due to exposure concerns. Aurora is pleased to offer Dialkyl phthalate reference standards, including isomerically pure nonyl and decyl phthalates. Other phthalates are available on a custom basis. 

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Dyes

Alcohol Diagnostics

Amide standards

As part of its interest in diagnostic reagents, Aurora offers fluorescent and visible dyes for research.

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Amide standards

Acylation Reagents

Amide standards

Aurora offers aliphatic benzamide and cinnamide standards for use in education or diagnostic applications.

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Acylation Reagents

Acylation Reagents

Acylation Reagents

Reagents to promote solution-phase acylation reactions and amine selective   derivatization reagents for enhanced detection and solubility properties.

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Other products

Acylation Reagents

Acylation Reagents

Small molecule organic compounds available in high purity. Moreover, Aurora has custom synthesis capability for all of your compound needs.

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